Mpox epidemiology, the 2022 global outbreak, JYNNEOS vaccine efficacy and safety data, and current vaccination recommendations.
Mpox (formerly monkeypox) is a viral zoonotic disease caused by the mpox virus, which belongs to the Orthopoxvirus genus (the same genus as smallpox). The disease was first identified in humans in 1970 in the Democratic Republic of Congo.
Mpox typically presents with fever, headache, muscle aches, and a characteristic rash that progresses through stages. While usually self-limiting, severe cases can occur, particularly in immunocompromised individuals, pregnant women, and young children.
JYNNEOS (also known as Imvanex in Europe) is a non-replicating modified vaccinia Ankara (MVA) vaccine. It was originally developed by Bavarian Nordic for smallpox but received FDA approval for mpox in July 2022. It contains a weakened form of the vaccinia virus that cannot replicate in human cells.