Burden of pneumococcal disease across age groups, the different pneumococcal conjugate vaccines (PCV7, PCV13, PCV15, PCV20), serotype coverage, and effectiveness data.
Pneumococcal disease is caused by Streptococcus pneumoniae (pneumococcus) bacteria. It causes a range of illnesses from mild ear infections to severe pneumonia, meningitis, and bloodstream infections (sepsis).
Pneumococcus is a leading cause of bacterial pneumonia in adults and otitis media (ear infection) in children. The bacteria can also cause meningitis, particularly dangerous in young children and older adults.
Pneumococcal conjugate vaccines (PCVs) have evolved significantly since the first licensed in 2000, with each generation covering more serotypes.
Covered 7 serotypes (4, 6B, 9V, 14, 18C, 19F, 23F). Introduced dramatic decline in invasive pneumococcal disease caused by these serotypes in children.
Added 6 additional serotypes (1, 3, 5, 6A, 7F, 19A). Now covers serotypes causing majority of childhood pneumococcal disease in U.S.
Adds 2 additional serotypes (22F, 33F) beyond PCV13. Covers approximately 75% of invasive pneumococcal disease in U.S. adults.
Adds 7 additional serotypes (8, 10A, 11A, 12F, 15B, 22F, 33F) to PCV13. Single vaccine can provide broader coverage than PCV15 + PPSV23.