Hepatitis B

A liver infection caused by HBV. It can become chronic and lead to liver cancer, cirrhosis, and death. The vaccine is the first anti-cancer vaccine.

Overview

Hepatitis B is a liver infection caused by the hepatitis B virus (HBV). It can cause acute illness with symptoms like jaundice, fatigue, and nausea, or become a chronic infection. Chronic HBV affects over 290 million people globally and causes approximately 820,000 deaths annually from liver cancer and cirrhosis (WHO, 2024).

In the United States, about 1.2 million people have chronic hepatitis B. The virus is transmitted through blood, semen, and other body fluids, either sexually or through sharing needles, razors, or other items contaminated with infected blood.

Vaccine and Recommendations

Hepatitis B Vaccine

  • Type: Recombinant subunit (HBsAg protein)
  • Schedule: Birth, 1-2 months, 6-18 months (3-dose series)
  • Efficacy: >90% in healthy adults, nearly 100% in infants
  • Duration: At least 30 years of protection in most recipients

CDC Recommendations

  • • All infants should receive first dose within 24 hours of birth
  • • All unvaccinated adults at risk should be vaccinated
  • • People with diabetes, liver disease, or HIV should be vaccinated
  • • International travelers to endemic regions should be vaccinated

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